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Is CD45.1/ CD45.2 CD45?

Source: Elabscience®Published: Mar 04,2024

No, they are not. CD45.1 and CD45.2 are subtype marker forms on the surface of immune cells and belong to the CD45 (cluster of differentiation 45) family. CD45 is a receptor protein tyrosine phosphatase, widely expressed in a variety of immune cells, such as T cells, B cells, macrophages and so on. CD45 exists in several subtypes, including CD45.1 and CD45.2. These two subtypes are mainly determined by different alleles on the CD45 gene. In experiments, the introduction of alleles of CD45.1 or CD45.2 can be used to distinguish between cells of different origin. The mouse strains expressing CD45.1 include FVB, RIII, SJL/J, STS/A, DA, etc. The mouse strains expressing CD45.2 included AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129, etc.