Immunology covers the study of all aspects of the immune system. As an important branch of the medical and biological sciences, immunology focuses on the structure and function of cellular components in the immune system, the characteristics of immune responses, the mechanisms of host defense against pathogens. The immune system protects the body against attacks by “foreign” invaders. The fundamental defects in the immune system can result in human diseases, such as autoimmune diseases, inflammatory diseases, and cancer.
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NF-κB is a family of transcription factor proteins including Rel (c-Rel), RELB, RelA/p65, NFκB1 p50/p105, and NFκB2 p52/p100. These proteins act as dimerization transcription factors that regulate gene expression and can affect a variety of biological processes including innate and adaptive immunity, inflammation, stress response, B cell development, and lymphoid organ formation.
JAK-STAT signaling pathway is a signal transduction pathway stimulated by cytokines. Compared with other signaling pathways, this signal transduction pathway is relatively simple.