Metabolism is a collection of chemical reactions catalyzed by enzymes in the living state of the cells and the organism. It converts the fuel in the biochemicals into the energy to run cellular processes, resulting in achievement of the material exchange, self-renewal as well as the relative stability of the internal environment. Metabolism disorder can lead to diseases including obesity, diabetes, lipidemia, hepatic lipidosis, and so on.
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Adenylate-activated protein kinase (AMPK) is a key molecule in the regulation of bioenergy metabolism which exists as a heterotrimeric complex consist of an α-catalytic subunit, a β-regulatory subunit, and a γ-regulatory the composition of subunits.