Journal: Nature Communications IF： 12.121(2019)This study highlights a direct link between ISG15/ISGylation and metabolic plasticity in PaCSCs, and strongly argues for further research into the development of inhibitors of ISG15/ISGylation for pancreatic ductal adenocarcinoma (PDAC).
Journal: JACS IF： 14.612(2019)The developed NaHCO3–TNLs can target bone surfaces and respond to external secreted acidification from osteoclasts, preventing osteoporosis.This study provided a novel understanding of osteoporosis therapy in biomedicine and clinical treatments.
Journal: Cell IF： 38.637(2019)This study reported that A mitochondrial circRNA that is dysregulated in NAFLD patients’ liver fibroblasts directly binds and regulates the mitochondrial permeability transition pore to modulate mitochondrial metabolism and inflammation, providing a potential therapeutic angle.
Journal: Immunity IF： 22.553(2019)This study reported a mechanistic understanding of how a minor haplotype of 10q26 locus conveys the strongest genetic risk for age-related macular degeneration (AMD), indicating that CD47 agonists and OPN inhibitors can be a potential treatment of AMD.
Journal: Biomaterials IF： 10.273(2019)CRISPR/Cas9 system and small molecule drugs can be co-delivered by virus-like nanoparticle (VLN) for malignant cancer treatment. VLN can disrupt multiple immunosuppressive pathways and suppress the growth of melanoma by loading a single guide RNA (sgRNA) targeting PDL-1and Axitinib.
Journal: Bone Research IF： 11.508(2019)This study reported the new mechanism of controlling sensory innervation in bone, indicating that the signaling profile associated with osteoblast phenotype differentiating program can regulate the patterning of sensory innervation, and also highlight osteoblast-derived Shh as an essential player in this cue-induced regulation.
Journal: Cell Stem Cell IF： 20.86(2019)This study reported that human tau accumulation in dentate gyrus GABAergic interneurons disrupts AHN and strengthening GABAergic signaling restores AHN and improves cognition in an AD mouse model, this study also suggests potential therapeutic avenues that could alleviate AD related AHN deficits.
Journal: Science Translational Medicine IF： 17.161This study demonstrated that the activation of the nuclear receptor PXR distinctly weakened AKI possibly by ameliorating mitochondrial dysfunction in ROS production, mitophagy, and lipid metabolism via transcriptional regulation of Akr1b7.
Journal: Nature IF： 42.778(2019)This study reported the new mechanism of DNA of Neutrophil extracellular traps (NETs) promoting cancer metastasis, indicating that NET-DNA acts as a chemotactic factor to attract cancer cells and a transmembrane DNA receptor that mediates NET-dependent metastasis. This research also suggests that targeting CCDC25 could be an appealing therapeutic strategy for the prevention of cancer metastasis.
Journal: Advanced Materials IF： 27.398 (2019)This study proposed a type of double locked nanoparticles (DLNP) which can limit the activation of CRISPR / Cas13a into tumor tissues. By replacing specific cRNA targeted genes, DLNP will become a potential universal platform for safe and effective cancer immunotherapy.