AANAT Polyclonal Antibody

Uniprot : Q16613
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14757

      Synonyms:AA-NAT,Aanat,Aralkylamine N-acetyltransferase,Arylalkylamine N acetyltransferase,Serotonin acetylase,Serotonin N-acetyltransferase,SNAT,SNAT

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms AA-NAT,Aanat,Aralkylamine N-acetyltransferase,Arylalkylamine N acetyltransferase,Serotonin acetylase,Serotonin N-acetyltransferase,SNAT,SNAT
      Swissprot Q16613
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human AANAT
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:50-1:200
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm.
      Tissue specificity Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using AANAT Polyclonal Antibody at dilution 1:40

      Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using AANAT Polyclonal Antibody at dilution 1:40

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