Purified Anti-Mouse CD105 Antibody[MJ7/18], Functional Grade (E-AB-F12330)
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For research use only.
| Alternate Names | HHT, ORW1, AI528660, AI662476, CD105, END, Endo, Endoglin, HHT1, ORW, S-endoglin, Edg, Eng, END, HHT1, ORW, ORW1, CD 105, CD105 antigen, EGLN, FLJ41744, Osler Rendu Weber syndrome 1, RP11 228B15.2, SN6 |
| Clone | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: Bend.3 |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume;Activ Reported in the literature |
| Background | Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Immunogen | Recombinant Human CD105 protein |
| Abbre | CD105 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG2a, κ |
| Isotype Control | Purified Rat IgG2a, κ Isotype Control[2A3], Functional Grade |
| Applications |
FCM;Activ
|
| Concentration |
≥ 3 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Application References | Kinderlerer AR, et al. Blood. 2009 Feb 12;113(7):1598-1607. |
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