CBFA2T3 Polyclonal Antibody (E-AB-19667)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer |
| Dilution | IHC 1:30-1:150 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CBFA2T3 |
| Abbre | CBFA2T3 |
| Synonyms | Cbfa2t3, Ccore binding factor runt domain alpha subunit 2 translocated to 3, ETO2, MTG16, MTG8 related gene 2, MTG8 related protein MTG16a, MTG8 related protein MTG16b, MTG8-related protein 2, MTGR2, Myeloid translocation gene 8 and 16, hMTG16, hMTG16a, hMTG16b |
| Swissprot | |
| Cellular Localization | Nucleus>nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm and Nucleus>nucleoplasm. Golgi apparatus membrane. |
| Concentration | 1.1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. |
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