Synonyms:ARMD10,CD284,CD284 antigen,Homolog of Drosophila toll,hToll,TLR 4,TLR4,TLR4,TOLL,Toll like receptor 4,Toll-like receptor 4
|Synonyms||ARMD10,CD284,CD284 antigen,Homolog of Drosophila toll,hToll,TLR 4,TLR4,TLR4,TOLL,Toll like receptor 4,Toll-like receptor 4|
|Immunogen||Synthesized peptide derived from the Internal region of human CD284.|
|Application||WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF,ELISA|
|Recommended dilution||WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:40000|
|Tissue specificity||Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4|
|Background||The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.|
Western Blot analysis of KB, Hela cells using CD284 Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human stomach cancer tissue using CD284 Polyclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Human stomach tissue using CD284 Polyclonal Antibody at dilution of 1:200.