Alternate Names	MAFA, 2F1-Ag
Swissprot	Q96E93,O88713
Gene ID	10219,50928
References	1. Faraco,G, et al. 2018. Nat Neurosci. 21(2): 240-249. 2. Xiong H, et al. 2016. Cell. 03.017. 3. Coffelt S, et al. 2015. Nature. 522(7556): 345-348. 4. Naik S, et al. 2015. Nature. 520(7545): 104-108. 5. Sell S, et al. 2015. PLoS Pathog. 11(2): e1004481.

Product Details

Form	Liquid
Clone No.	2F1(See Other Available Formats)
Host	Syrian Hamster
Isotype	Syrian Hamster IgG
Isotype Control	FITC Syrian Hamster IgG Isotype Control[SHG-1] [Product E-AB-F09762C]
Reactivity	Human,Mouse
Application	FCM (See the Application Description)
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	FITC
	FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).

How to select the appropriate detection channel through the spectrogram?

Background

Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG4 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.

Protocols & Troubleshootings

Related Protocols	Staining Cell Surface Targets for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
PE Anti-Human/Mouse KLRG-1 Antibody[2F1]	20Tests, 100Tests, 100Tests×2	Check More
APC Anti-Human/Mouse KLRG-1 Antibody[2F1]	20Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine7 Anti-Human/Mouse KLRG-1 Antibody[2F1]	20Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® Violet 450 Anti-Human/Mouse KLRG-1 Antibody[2F1]	20Tests, 100Tests, 100Tests×2	Check More
FITC Anti-Human/Mouse KLRG-1 Antibody[2F1]	25μg, 100μg	Check More
PE Anti-Human/Mouse KLRG-1 Antibody[2F1]	25μg, 100μg	Check More
APC Anti-Human/Mouse KLRG-1 Antibody[2F1]	25μg, 100μg	Check More
PE/Cyanine7 Anti-Human/Mouse KLRG-1 Antibody[2F1]	25μg, 100μg	Check More
Elab Fluor^® Violet 450 Anti-Human/Mouse KLRG-1 Antibody[2F1]	25μg, 100μg	Check More

Citations

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