MMP12 Polyclonal Antibody

Uniprot : P39900
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14217

      Synonyms:EC 3.4.24.65,HME,Macrophage elastase,Macrophage metalloelastase,Macrophage metaloelastase,Matrix metallopeptidase 12 (macrophage elastase),Matrix metalloprotease 12,Matrix metalloproteinase-12,ME,MGC138506,MME,MMP 12,MMP-12,Mmp12,MMP12

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms EC 3.4.24.65,HME,Macrophage elastase,Macrophage metalloelastase,Macrophage metaloelastase,Matrix metallopeptidase 12 (macrophage elastase),Matrix metalloprotease 12,Matrix metalloproteinase-12,ME,MGC138506,MME,MMP 12,MMP-12,Mmp12,MMP12
      Swissprot P39900
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant protein of human MMP12
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:50-1:200
      Concentration 0.8 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Secreted>extracellular space>extracellular matrix.
      Tissue specificity Found in alveolar macrophages but not in peripheral blood monocytes.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin.

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MMP12 Polyclonal Antibody at dilution of 1:60

      Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MMP12 Polyclonal Antibody at dilution of 1:60

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