NF2 Polyclonal Antibody

Uniprot: P35240
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-40301

      Synonyms:ACN,BANF,Bilateral acoustic neuroma,MERL,Merlin,Moesin ezrin radixin like protein,Moesin ezrin radizin like,Moesin-ezrin-radixin-like protein,Neurofibromatosis 2,Neurofibromatosis type 2,Neurofibromatosis2,Neurofibromin 2,Neurofibromin-2,Neurofibromin2,NF 2,Nf2,SCH,Schwannomerlin,Schwannomin

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Reactivity: H

      Applications: IHC

      Lead Time: 7~10daysWelcome to order from local distributors.

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      Overview

      Synonyms ACN,BANF,Bilateral acoustic neuroma,MERL,Merlin,Moesin ezrin radixin like protein,Moesin ezrin radizin like,Moesin-ezrin-radixin-like protein,Neurofibromatosis 2,Neurofibromatosis type 2,Neurofibromatosis2,Neurofibromin 2,Neurofibromin-2,Neurofibromin2,NF 2,Nf2,SCH,Schwannomerlin,Schwannomin
      Swissprot P35240
      Reactivity Human
      Immunogen Recombinant Human Merlin protein
      Application IHC
      Recommended dilution IHC 1:100-1:200
      Concentration 2mg/mL

      Properties

      Cellular localization Cytoplasm > perinuclear region
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.4.
      Background This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

      Images

      Immunohistochemistry of paraffin-embedded Human pancreatic cancer using NF2 Polyclonal Antibody at dilution of 1:100(100×)

      Immunohistochemistry of paraffin-embedded Human pancreatic cancer using NF2 Polyclonal Antibody at dilution of 1:100(400×)

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