PE Anti-Mouse CD272/BTLA Antibody[PK18.6]

All	Size	Price	Qty
	100μg	$ 228.00
	25μg	$ 86.00

Alternate Names	B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, Btla, CD272
Clone No	PK18.6
Leadtime	Order now, ship in 3 days
Background	CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
Abbre	CD272
Swissprot	Q7TSA3
Host	Rat
Reactivity	Mouse
Clonality	Monoclonal
Isotype	Rat IgG1, κ
Isotype Control	E-AB-F09823D
Applications	FCM
Research Areas	Immunology;Inhibitory Molecules
Cellular Localization	Membrane
Form	Liquid
Concentration	0.2 mg/mL
Conjugation	PE
Conjugation Information	PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
Spectrum
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration Date	12 months
Shipping	Ice bag

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E-CK-A107	Cell Staining Buffer	500mL , 200mL , 100mL

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PE Anti-Mouse CD272/BTLA Antibody[PK18.6] (E-AB-F1024UD)

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