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Recombinant 2019-nCoV Methyltransferase / ME Protein (His Tag)

Uniprot : YP_009724390.1

Cat.No.:PKSR030513
Expression host: E. coli

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100µg

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Description

Synonyms	Methyltransferase, ME
Species	virus
Expression_host	E. coli
Sequence	Ser6799-Asn7096
Accession	YP_009724390.1
Mol_Mass	33.46 kDa.
Tag	C-His

Properties

Purity	> 85 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per µg as determined by the LAL method.
Storage	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile 20 mM Tris 150 mM NaCl, pH 8.3.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Coronavirus encodes the 2'-O-MTase（2'O Methyltransferase） that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design in an expanding Coronavirus outbreak setting, such as COVID-19. Targeting on the 2'O-methylation pathway on SARS-CoV replication and pathogenesis can be the treatment options for vaccine and anti-viral durgs development which can against SARS-CoV-2，SARS-CoV, MERS-CoV or other RNA and DNA viruses.

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