Recombinant 2019-nCoV S1 Protein (Fc Tag)(Active)

    • Recombinant Rat CRP/C-Reactive Protein (His Tag)-Elabsicence
    • Recombinant 2019-nCoV S1 Protein (Fc Tag)-Elabscience
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    • Recombinant Rat CRP/C-Reactive Protein (His Tag)-Elabsicence
    • Recombinant 2019-nCoV S1 Protein (Fc Tag)-Elabscience
    • Recombinant Rat CRP/C-Reactive Protein (His Tag)-Elabsicence
    • Recombinant 2019-nCoV S1 Protein (Fc Tag)-Elabscience

      Catalog number:PKSR030480

      Synonyms:S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein

      Size:
      • 50µg
      • 1mg
      Qty:
      - +
      Price: $253

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
      Species Virus
      Expression_host Human Cells
      Sequence Gln14-Arg685
      Accession QHD43416.1
      Application Immunogen, calibrator or standard.
      Mol_Mass 102.2 kDa
      AP_Mol_Mass 130-140 kDa
      Tag C-Fc
      Bio_Activity Immobilized Human ACE-2-Fc(Cat#PKSR030492) at 10μg/ml (100 μl/well) can bind Recombinant 2019-nCoV S1 Protein (Fc Tag) (Cat#PKSR030480). Biotinylated by NHS-biotin prior to testing. The ED50 of PKSR030480 is 0.85 ug/ml.

      Properties

      Purity > 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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