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Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag)

Uniprot : H0VUB1
  • Cat.No.:PKSQ050093

  • Expression host: P.Pichia

To Purchase PKSQ050093

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  • 10µg
  • 50µg
Price: $263
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Description

Synonyms Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4
Species Cavia porcellus
Expression_host P.Pichia
Sequence Ala37-Asp161
Accession H0VUB1
Application Functional ELISA
Mol_Mass 14.1 kDa
AP_Mol_Mass 18-40 kDa
Tag C-His
Bio_Activity Immobilized Mouse B7-1-Fc(Cat: PKSM041366) at 1μg/ml(100 μl/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Cavia porcellus CTLA-4-His is 0.17ug/ml .

Properties

Purity > 90% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

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