Recombinant Cynomolgus B2M/Beta-2-microglobulin Protein (His Tag)

    • Recombinant Cynomolgus B2M / Beta-2-microglobulin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    <
    >
    • Recombinant Cynomolgus B2M / Beta-2-microglobulin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus B2M / Beta-2-microglobulin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050038

      Synonyms:Beta-2-Microglobulin; B2M; β2-Microglobulin

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $111

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Beta-2-Microglobulin; B2M; β2-Microglobulin
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Ile21-Met119
      Accession Q8SPW0
      Mol_Mass 12.5 kDa
      AP_Mol_Mass 14 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

      Image

      submit review
      • Show all (0)
      • Reviews (0)
      • Q&A (0)
      ... Show All Show Less
      MSDS for ELISA ISO 9001

      Browsing History


        People Also Bought

        Apply for Free Shipping 24T ELISA Kit
        *Product Name:
        *Catalog Number:
        Size:
        *Name:
        *Email:
        *Phone:
        *Message:
        *Country:
        How do you know
        Elabscience:

        *Verification code: