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Recombinant Cynomolgus B7-2/CD86 Protein (Fc Tag)

Uniprot : G7NXR4
  • Cat.No.:PKSQ050017

  • Expression host: Human Cells

To Purchase PKSQ050017

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  • 10µg
  • 50µg
Price: $70
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Description

Synonyms T-lymphocyte activation antigen CD86 isoform 1;Activation B7-2 antigen; CD86
Species Cynomolgus
Expression_host Human Cells
Sequence Ala19-His240
Accession G7NXR4
Mol_Mass 52.5 kDa
AP_Mol_Mass 90-120 kDa
Tag C-Fc

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
Reconstitution Please refer to the printed manual for detailed information.

Background

T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.

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