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Recombinant Cynomolgus B7-H3/CD276 Protein (Fc Tag)

  • Cat.No.:PKSQ050036

  • Expression host: Human Cells

To Purchase PKSQ050036

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  • 10μg
  • 50μg
Price: $178
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Description

Synonyms CD276 antigen; CD276; B7 homolog 3; B7-H3;CD276
Species Cynomolgus
Expression_host Human Cells
Sequence Leu29-Glu465
Accession XP_015308534
Mol_Mass 74 kDa
AP_Mol_Mass 110-130 kDa
Tag C-Fc

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.

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