Recombinant Cynomolgus B7-H3/CD276 Protein (His Tag)

    • Recombinant Cynomolgus B7-H3 / CD276 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Cynomolgus B7-H3 / CD276 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus B7-H3 / CD276 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050052

      Synonyms:CD276 antigen; CD276; B7 homolog 3; B7-H3;CD276

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $178

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms CD276 antigen; CD276; B7 homolog 3; B7-H3;CD276
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Leu29-Glu465
      Accession XP_015308534
      Mol_Mass 47.9 kDa
      AP_Mol_Mass 70-90 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.

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