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Recombinant Cynomolgus CD40/TNFRSF5/CD40L Receptor Protein (Fc Tag)

  • Cat.No.:PKSQ050044

  • Expression host: Human Cells

To Purchase PKSQ050044

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  • 10μg
  • 50μg
Price: $117
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Description

Synonyms Tumor Necrosis Factor Receptor Superfamily member 5; B-Cell Surface Antigen CD40; Bp50; CD40L Receptor; CDw40; CD40; TNFRSF5
Species Cynomolgus
Expression_host Human Cells
Sequence Glu21-Arg193
Accession G7PG38
Mol_Mass 46.3 kDa
AP_Mol_Mass 30&35&60 kDa
Tag C-Fc

Properties

Purity > 90% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
Reconstitution Please refer to the printed manual for detailed information.

Background

CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.

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