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Recombinant Cynomolgus CD40/TNFRSF5/CD40L Receptor Protein (Fc Tag)

Uniprot : A0A2K5V585

Cat.No.:PKSQ050044
Expression host: HEK293 Cells

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Description

Synonyms	Tumor Necrosis Factor Receptor Superfamily member 5;B-Cell Surface Antigen CD40;Bp50;CD40L Receptor;CDw40;CD40;TNFRSF5
Species	Cynomolgus macaques
Expression_host	HEK293 Cells
Sequence	Glu21-Arg193
Accession	XP_005569275.1
Mol_Mass	46.3 kDa
AP_Mol_Mass	48-70 kDa
Tag	C-Fc

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the
Reconstitution	Please refer to the printed manual for detailed information.

Background

CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.

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