Recombinant Cynomolgus FGF-21/Fibroblast Growth Factor 21 Protein (His Tag)

    • Recombinant Cynomolgus FGF-21 / Fibroblast Growth Factor 21 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Cynomolgus FGF-21 / Fibroblast Growth Factor 21 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus FGF-21 / Fibroblast Growth Factor 21 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050041

      Synonyms:FGF21; Fibroblast Growth Factor 21;FGF-21

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms FGF21; Fibroblast Growth Factor 21;FGF-21
      Species Cynomolgus
      Expression_host Human Cells
      Sequence His29-Ser209
      Accession XM_005589811.2
      Mol_Mass 20.2 kDa
      AP_Mol_Mass 19-24 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation, or following the ingestionof a highly-fat/low-carbohydrate diet. Upon FGF21 secretion, white adipose tissue is induced to release free fatty acids from triglyceride stores. Once free fatty acid reach hepatocytes, they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies, release, and transported to peripheral tissue for TCA processing and energy generation.

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