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Recombinant Human Activin Receptor 2B/ACVR2B Protein (His Tag)

Uniprot : Q13705

Cat.No.:PKSH032040
Expression host: HEK293 Cells

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Description

Synonyms	Activin Receptor Type-2B;Activin Receptor Type IIB;ACTR-IIB;ACVR2B;Bone Morphogenetic Protein Receptor Type-2;BMP Type-2 Receptor;BMPR-2;Bone Morphogenetic Protein Receptor Type II;BMP Type II Receptor
Species	Human
Expression_host	HEK293 Cells
Sequence	Ser19-Thr134
Accession	Q13705
Mol_Mass	14.4 kDa
AP_Mol_Mass	25-38 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed man
Reconstitution	Please refer to the printed manual for detailed information.

Background

Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.

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