Recombinant Human ADK Protein (His & GST tag)

    • Recombinant Human ADK Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human ADK Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human ADK Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030331

      Synonyms:AK

      Size:
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms AK
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-His 345
      Accession AAH03568.1
      Mol_Mass 68 kDa
      AP_Mol_Mass 60 kDa
      Tag N-His & GST

      Properties

      Purity > 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 10% gly, 0.3mM DTT
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Adenosine kinase(ADK) belongs to the family of transferases. Adenosine kinase (ADK) is the key enzyme in adenosine metabolism and catalyzes ATP and adenosine into two products: ADP and AMP. Two isoforms of the enzyme adenosine kinase (ADK), which differ at their N-terminal ends, are found in mammalian cells. It has been shown that the two ADK isoforms differ only in their first exons and the promoter regions; hence they arise via differential splicing of their first exons with the other exons common to both isoforms. In adult brain, ADK is primarily present in astrocytes. Several lines of experimental evidence support a critical role of ADK in different types of brain injury associated with astrogliosis, which is also a prominent morphologic feature of temporal lobe epilepsy (TLE). It has been suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of TLE. Moreover, in vitro data suggest the existence of an additional layer of modulatory crosstalk between the astrocyte-based adenosine cycle and inflammation. ADK also contributes to CK homeostasis in vivo. 

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