Recombinant Human Artemin Protein

    • Recombinant Human Artemin Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Artemin Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Artemin Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033760

      Synonyms:Artemin; ARTN; Enovin; Neublastin; EVN

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $111

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Artemin; ARTN; Enovin; Neublastin; EVN
      Species Human
      Expression_host E.coli
      Sequence Ala108-Gly220
      Accession Q5T4W7
      Mol_Mass 12.1 kDa
      AP_Mol_Mass 14 kDa

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. In the mature region, human ARTN is 89% and 88% aa identical to rat and mouse ARTN, respectively. Human ARTN is active on rodent cells. The receptor for ARTN has been identified as the ligand binding subunit GFRα-3 plus the signal transducing subunit, RET. The GFRα-1/RET receptor complex has also been suggested to be a ligand binding unit for ARTN. ARTN is known to be a chemoattractant for sympathetic neuron axons innervating the developing cardiovascular system. It also promotes sensory neuron survival and likely plays a role in the development of the peripheral nervous system. Finally, it has been reported to reverse neuropathic pain due to nerve injury, and to help resolve morphological changes associated with nerve damage.

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