Recombinant Human BCMA/TNFRSF17 Protein (His Tag)

    • Recombinant Human BCMA / TNFRSF17 / CD269 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human BCMA / TNFRSF17 / CD269 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human BCMA / TNFRSF17 / CD269 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033486

      Synonyms:Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269;TNFRSF17; BCM; BCMA

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $92

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      Overview

      Synonyms Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269;TNFRSF17; BCM; BCMA
      Species Human
      Expression_host P.Pichia
      Sequence Met1-Ala54
      Accession Q02223
      Mol_Mass 6.9 kDa
      AP_Mol_Mass 12&15-28 kDa
      Tag C-His

      Properties

      Purity > 90% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

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      MSDS for ELISA ISO 9001

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