Recombinant Human BTLA/CD272 Protein (His Tag)(Active)

    • Recombinant Human BTLA / CD272 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human BTLA / CD272 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human BTLA / CD272 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033758

      Synonyms:B- and T-Lymphocyte Attenuator; B- and T-Lymphocyte-Associated Protein; CD272; BTLA

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $86

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms B- and T-Lymphocyte Attenuator; B- and T-Lymphocyte-Associated Protein; CD272; BTLA
      Species Human
      Expression_host Human Cells
      Sequence Lys31-Leu150
      Accession Q7Z6A9-2
      Application Functional ELISA
      Mol_Mass 14.79 kDa
      AP_Mol_Mass 30 kDa
      Tag C-His
      Bio_Activity Immobilized Human HVEM at 1μg/ml(100 μl/well) can bind Human BTLA-His.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

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      MSDS for ELISA ISO 9001

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