Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active)

    • Recombinant Human Cathepsin S / CTSS Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Cathepsin S / CTSS Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Cathepsin S / CTSS Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033736

      Synonyms:Cathepsin S;CTSS;CTSS;MGC3886

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $263

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Cathepsin S;CTSS;CTSS;MGC3886
      Species Human
      Expression_host Human Cells
      Sequence Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide)
      Accession P25774
      Mol_Mass 36.9&25&11.2 kDa
      AP_Mol_Mass 37-40&26-28&14-16 kDa
      Tag C-His
      Bio_Activity Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 The specific activity is 9063.642 pmol/min/µg.

      Properties

      Purity > 90% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease(AD) and Down Syndrome (DS).

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      MSDS for ELISA ISO 9001

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