Recombinant Human CD153 / CD30L / TNFSF8 Protein

    • Recombinant Human CD153 / CD30L / TNFSF8 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human CD153 / CD30L / TNFSF8 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human CD153 / CD30L / TNFSF8 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030309

      Synonyms:CD153;CD30L;CD30LG

      Size:
      • 50 µg
      • 200 µg
      Qty:
      - +
      Price: $389

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms CD153;CD30L;CD30LG
      Species Human
      Expression_host HEK293 Cells
      Sequence Gln 63-Asp 234
      Accession NP_001235.1
      Mol_Mass 19.6 kDa

      Properties

      Purity > 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.

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