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Recombinant Human CD16a/FCGR3A Protein (176 Phe, His&AVI Tag)

Uniprot : P08637

Cat.No.:PKSH030285
Expression host: HEK293 Cells

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100μg
1mg

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Description

Synonyms	Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A;CD16a Antigen;Fc-Gamma RIII-Alpha;Fc-Gamma RIII;Fc-gamma RIIIa;FcRIII;FcRIIIa;FcR-10;IgG Fc Receptor III-2;CD16a;FCGR3A;CD16A;FCG3;FCGR3;IGFR3;CD16;CD16A
Species	Human
Expression_host	HEK293 Cells
Sequence	Met 1-Gln 208
Accession	P08637-1
Mol_Mass	25.1 kDa
AP_Mol_Mass	46 kDa
Tag	C-His-Avi
Bio_Activity	Using the Octet RED System, the affinity constant (Kd) of CD16a bound to Human IgG1 was 30nM.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.2 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

The Fc receptor with low affinity for IgG (FCGR3; or CD16) is encoded by 2 nearly identical genes; FCGR3A and FCGR3B; resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A; it is also known as CD16a; encodes a transmembrane protein expressed on activated monocytes/macrophages; natural killer (NK) cells; and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells; independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells; independent of antibody ligation.

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