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Recombinant Human CD172a/SIRPA Protein (His Tag)(Active)

    • Recombinant Human CD172a / SIRPA Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human CD172a / SIRPA Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human CD172a / SIRPA Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033525

      Synonyms:Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; SHP Substrate 1; SHPS-1; Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs; Bit; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion Receptor; MyD-1 Antigen; Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1; Signal-Regulatory Protein Alpha-2; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $86

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      Overview

      Synonyms Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; SHP Substrate 1; SHPS-1; Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs; Bit; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion Receptor; MyD-1 Antigen; Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1; Signal-Regulatory Protein Alpha-2; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
      Species Human
      Expression_host Human Cells
      Sequence Glu31-Arg370
      Accession CAA71403.1
      Application Functional ELISA
      Mol_Mass 38.31 kDa
      AP_Mol_Mass 45-65 kDa
      Tag C-His
      Bio_Activity Immobilized Human CD47-Fc(Cat: PKSH032703) at 2μg/ml(100 μl/well) can bind Human SIRPA-His. The ED50 of Human SIRPA-His is 0.49ug/ml .

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation

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      MSDS for ELISA ISO 9001

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