Recombinant Human CD20 / MS4A1 Protein (TrxA Tag)

    • Recombinant Human CD20 / MS4A1 Protein (TrxA Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human CD20 / MS4A1 Protein (TrxA Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human CD20 / MS4A1 Protein (TrxA Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030304

      Synonyms:B1;Bp35;CD20;CVID5;LEU-16;MS4A1;MS4A2;S7

      Size:
      • 100 µg
      Qty:
      - +
      Price: $963

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms B1;Bp35;CD20;CVID5;LEU-16;MS4A1;MS4A2;S7
      Species Human
      Expression_host E.coli
      Sequence Ile 141-Ser 188
      Accession NP_068769.2
      Mol_Mass 23.9 kDa
      Tag N-TrxA

      Properties

      Purity > 80 % as determined by reducing SDS-PAGE.
      Endotoxin Please contact us for more information.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 1 mM EDTA, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

      SDS-PAGE

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