Recombinant Human CD226/DNAM-1 Protein (His Tag)

    • Recombinant Human CD226 Antigen / DNAM-1 / CD226 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human CD226 Antigen / DNAM-1 / CD226 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human CD226 Antigen / DNAM-1 / CD226 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033728

      Synonyms:CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD226; DNAM1

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $92

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      Overview

      Synonyms CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD226; DNAM1
      Species Human
      Expression_host Human Cells
      Sequence Glu19-Asn247
      Accession Q15762
      Mol_Mass 26.8 kDa
      AP_Mol_Mass 43-55 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Human DNAX accessory molecule 1 (DNAM-1/CD226) is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Mature human DNAM-1 contains an extracellular domain (ECD) with two Ig-like C2-set domains and a cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155 and CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, dendritic cell maturation, megakaryocyte and activated platelet adhesion to vascular endothelial cells, and monocyte extravasation; it inhibits the forrmation of osteoclasts. Plateletendothelium, interactions mediated by DNAM-1, enable the metastasis of tumor cells to the lung.

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      MSDS for ELISA ISO 9001

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