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Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag)

  • Cat.No.:PKSH033470

  • Expression host: E.coli

To Purchase PKSH033470

Size:
  • 10μg
  • 50μg
Price: $447
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Description

Synonyms Claudin-18; CLDN18
Species Human
Expression_host E.coli
Sequence Asp28-Leu76
Accession P56856-2
Mol_Mass 19.7 kDa
AP_Mol_Mass 18 kDa
Tag N-8His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 25mM NaCl, 10% glycerol, pH 8.0.
Reconstitution Please refer to the printed manual for detailed information.

Background

Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

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