Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag)

    • Recombinant Human CLDN18.2 / Claudin-18 A2 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human CLDN18.2 / Claudin-18 A2 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human CLDN18.2 / Claudin-18 A2 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033470

      Synonyms:Claudin-18; CLDN18

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $447

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      Overview

      Synonyms Claudin-18; CLDN18
      Species Human
      Expression_host E.coli
      Sequence Asp28-Leu76
      Accession P56856-2
      Mol_Mass 19.7 kDa
      AP_Mol_Mass 18 kDa
      Tag N-8His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 25mM NaCl, 0.1% Triton X-100, 10% glycerol, pH 8.0.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

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      MSDS for ELISA ISO 9001

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