Recombinant Human CNTF Protein (Active)

    • Recombinant Human CNTF / Ciliary neurotrophic factor Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human CNTF / Ciliary neurotrophic factor Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human CNTF / Ciliary neurotrophic factor Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033716

      Synonyms:Ciliary Neurotrophic Factor; CNTF

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $144

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      Overview

      Synonyms Ciliary Neurotrophic Factor; CNTF
      Species Human
      Expression_host E.coli
      Sequence Ala2-Met200
      Accession P26441
      Application Cell Culture
      Mol_Mass 22.93 kDa
      AP_Mol_Mass 25 kDa
      Bio_Activity Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 25 ng/ml.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,1mM Cysteine,PH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.

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