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Recombinant Human Cystatin C/CST3 Protein (E.coli, His Tag)

Uniprot : P01034

Cat.No.:PKSH032324
Expression host: E.coli

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Description

Synonyms	ARMD11;Gamma-trace;Neuroendocrine basic polypeptide;Post-gamma-globulin;Cystatin-3
Species	Human
Expression_host	E.coli
Sequence	Gly26-Ala146
Accession	P01034
Mol_Mass	16.5 kDa
AP_Mol_Mass	16 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 1mM EDTA, 5% sucrose, 0.009% Tweem80, pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Cystatin C is a member of family 2 of the cystatin superfamily. It is ubiquitous in human tissues and body fluids and mainly used as a biomarker of kidney function. Cystatin C inhibits many cysteine proteases such as papain and Cathepsins B; H; K; L and S. As an inhibitor of cysteine proteinases; Cystatin C is thought to serve an important physiological role as a local regulator of this enzyme activity. Recently; it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition); such as Alzheimer's disease.

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