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Recombinant Human DR6/TNFRSF21 Protein (Fc Tag)(Active)

  • Cat.No.:PKSH031801

  • Expression host: HEK293 Cells

To Purchase PKSH031801

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  • 100μg
  • 200μg
Price: $486
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Description

Synonyms Tumor Necrosis Factor Receptor Superfamily Member 21; Death Receptor 6; CD358; TNFRSF21; DR6
Species Human
Expression_host HEK293 Cells
Sequence Met 1-Leu 350
Accession NP_055267.1
Application Functional ELISA
Mol_Mass 60.3 kDa
AP_Mol_Mass 95-100 kDa
Tag C-Fc
Bio_Activity Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human DR6-Fc at 10 μg/mL (100 μl/well) can bind biotinylated human APP-Fc with a linear range of 0.03-0.25 μg/mL.

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

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