Recombinant Human ECE1 Protein (His Tag)

    • Recombinant Human Endothelin-converting Enzyme 1 / ECE1 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Endothelin-converting Enzyme 1 / ECE1 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Endothelin-converting Enzyme 1 / ECE1 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033691

      Synonyms:Endothelin-converting enzyme 1; ECE-1

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $178

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      Overview

      Synonyms Endothelin-converting enzyme 1; ECE-1
      Species Human
      Expression_host Human Cells
      Sequence Gln90-Trp770
      Accession P42892
      Mol_Mass 78.8 kDa
      AP_Mol_Mass 94-130 kDa
      Tag N-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Endothelin-Converting Enzyme-1 (ECE-1) is a single-pass type I I transmembrane (TM) protein with a short cytoplasmic tail and a large ectodomain. ECE-1 is a zinc protease of the neprilysin (NEP) family, which also includes ECE-2, PEX, XCE, DINE, and Kell, and several NEP-like proteins. It is widely expressed and has several alternatively spliced forms that differ in their TM domain or cytoplasmic tail. All isoforms of ECE-1 are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Endothelin-converting enzyme-1 is involved in the proteolytic processing of Endothelin-1 (EDN1), Endothelin-2 (EDN2), and Endothelin-3 (EDN3) to biologically active peptides. Defects in ECE1 are a cause of Hirschsprung disease, cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.

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