Recombinant Human ESAM Protein (aa 30-247, His Tag)

    • Recombinant Human ESAM / Endothelial Cell Adhesion Molecule Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human ESAM / Endothelial Cell Adhesion Molecule Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human ESAM / Endothelial Cell Adhesion Molecule Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033692

      Synonyms:Endothelial Cell-Selective Adhesion Molecule; ESAM

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $86

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      Overview

      Synonyms Endothelial Cell-Selective Adhesion Molecule; ESAM
      Species Human
      Expression_host Human Cells
      Sequence Gln30-Ala247
      Accession Q96AP7
      Mol_Mass 24.79 kDa
      AP_Mol_Mass 38 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules. The 390 amino acid Human ESAM contains a 216 amino acid extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential, and accordingly, overexpression of ESAM is closely associated with certain tumor growth and metastasis. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes. The ECD of human and mouse ESAM share 69% amino acid identity.

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