Recombinant Human Ezrin/EZR Protein

    • Recombinant Human Ezrin / EZR / VIL2 Protein-Elabscience
    • Recombinant Protein-Elabscience
    <
    >
    • Recombinant Human Ezrin / EZR / VIL2 Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Ezrin / EZR / VIL2 Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033684

      Synonyms:Ezrin; Cytovillin; Villin-2; p81; EZR; VIL2

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms Ezrin; Cytovillin; Villin-2; p81; EZR; VIL2
      Species Human
      Expression_host E.coli
      Sequence Met1-Leu586
      Accession P15311
      Mol_Mass 69.4 kDa
      AP_Mol_Mass 80 kDa

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 10mM Hepes, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.

      Image

      submit review
      • Show all (0)
      • Reviews (0)
      • Q&A (0)
      ... Show All Show Less
      MSDS for ELISA ISO 9001

      Browsing History


        People Also Bought

        Apply for Free Shipping 24T ELISA Kit
        *Product Name:
        *Catalog Number:
        Size:
        *Name:
        *Email:
        *Phone:
        *Message:
        *Country:
        How do you know
        Elabscience:

        *Verification code: