Recombinant Human FGFR3/CD333 Protein (Fc Tag)(Active)

    • Recombinant Human FGFR3 / CD333 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human FGFR3 / CD333 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human FGFR3 / CD333 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033678

      Synonyms:Fibroblast growth factor receptor 3; FGFR-3;FGFR3; JTK4; IIIc;ACH;CD333;CEK2;HSFGFR3EX

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $92

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Fibroblast growth factor receptor 3; FGFR-3;FGFR3; JTK4; IIIc;ACH;CD333;CEK2;HSFGFR3EX
      Species Human
      Expression_host Human Cells
      Sequence Glu23-Gly375
      Accession P22607
      Mol_Mass 64.8 kDa
      AP_Mol_Mass 95-110 kDa
      Tag C-Fc
      Bio_Activity Measured by its ability to inhibit FGF acidic-dependent proliferation of BALB/c 3T3 cells. The ED50 for this effect is 18.2 ng/ml.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Fibroblast growth factors (FGFs) are involved in a multitude of physiological and pathological cellular processes. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1-3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the α isoform, or only IgII and IgIII, referred to as the β isoform. Only the α isoform has been identified for FGF R3 and FGF R4. Additional splicing events for FGF R1-3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). The complex patterns of expression of these receptors as well as the specificity of their interactions with the various FGF ligand family members are under investigation.

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      MSDS for ELISA ISO 9001

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