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Recombinant Human FGL1 Protein (mFc Tag)(Active)

  • Cat.No.:PKSH033679

  • Expression host: Human Cells

To Purchase PKSH033679

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  • 10μg
  • 50μg
Price: $178
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Description

Synonyms Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1
Species Human
Expression_host Human Cells
Sequence Leu23-Ile312
Accession Q08830
Application Functional ELISA
Mol_Mass 60.6 kDa
AP_Mol_Mass 60-65 kDa
Tag C-mFc
Bio_Activity Immobilized Human LAG-3(Cat: PKSH033596) at 5μg/ml(100 μl/well) can bind Human FGL1-Fc. The ED50 of Human FGL1-Fc is 2.1 ug/ml.

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, 5% Thehalose, pH 7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Hepassocin, also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .

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