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Recombinant Human Hyaluronidase-1/HYAL1 Protein (His Tag)

Uniprot : Q12794

Cat.No.:PKSH032552
Expression host: HEK293 Cells

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Description

Synonyms	Hyaluronidase-1;Hyal-1;Hyaluronoglucosaminidase-1;Lung Carcinoma Protein 1;LuCa-1;HYAL1;LUCA1
Species	Human
Expression_host	HEK293 Cells
Sequence	Phe22-Trp435
Accession	Q12794
Mol_Mass	47.2 kDa
AP_Mol_Mass	50-65 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Reconstitution	Not Applicable

Background

Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

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