Recombinant Human IL10-RA/IL-10 Rα Protein (His Tag)

    • Recombinant Human IL10-RA / IL-10 Rα Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human IL10-RA / IL-10 Rα Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human IL10-RA / IL-10 Rα Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033632

      Synonyms:Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA; IL-10RA

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $178

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      Overview

      Synonyms Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA; IL-10RA
      Species Human
      Expression_host Human Cells
      Sequence His22-Asn235
      Accession Q13651
      Mol_Mass 25.2 kDa
      AP_Mol_Mass 38-59 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin-10 Receptor alpha (IL-10Rα) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 Rα consists of a 214 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 322 aa cytoplasmic domain. Within the ECD, human IL-10 Rα shares 59% aa sequence identity with mouse and rat IL-10Rα. IL-10 Rα is required for mediating the effects of IL-10,a critical molecule in the control of microbial infections, allergic and autoimmune inflammation, and cancer. IL-10Rα is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 Rα, resulting in the recruitment of IL-10 Rβ. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2, 4, or 9, enabling strengthened immune responses during infection. Polymorphisms of human IL-10 Rα may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.

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      MSDS for ELISA ISO 9001

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