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Recombinant Human IL-1 beta/IL1B Protein (pro form, His Tag)

Uniprot : P01584

Cat.No.:PKSH031840
Expression host: E.coli

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100μg
1mg

Price: $1218

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Description

Synonyms	IL-1;IL-1 beta;IL-1B;IL1-BETA;IL1F2
Species	Human
Expression_host	E.coli
Sequence	Met 1-Ser 269(Glu6Lys)
Accession	NP_000567.1
Application	Functional ELISA
Mol_Mass	32.3 kDa
AP_Mol_Mass	34 kDa
Tag	N-His
Bio_Activity	Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1.The EC50 of human IL1R1 is 0.198 μg/mL.

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	Please contact us for more information.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).

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