Recombinant Human IL-8 / CXCL8 Protein (aa 23-99)

    • Recombinant Human IL-8 / CXCL8 Protein (aa 23-99)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human IL-8 / CXCL8 Protein (aa 23-99)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human IL-8 / CXCL8 Protein (aa 23-99)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030276

      Synonyms:GCP-1;GCP1;IL-8;IL8;Interleukin-8;LECT;LUCT;LYNAP;MDNCF;MONAP;NAF;NAP-1;NAP1

      Size:
      • 50 µg
      • 100 µg
      Qty:
      - +
      Price: $389

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms GCP-1;GCP1;IL-8;IL8;Interleukin-8;LECT;LUCT;LYNAP;MDNCF;MONAP;NAF;NAP-1;NAP1
      Species Human
      Expression_host HEK293 Cells
      Sequence Ala 23-Ser 99
      Accession NP_000575.1
      Mol_Mass 8 kDa
      AP_Mol_Mass 12 kDa

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.

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