Recombinant Human JAM-A/F11R Protein (His Tag)

    • Recombinant Human F11 Receptor / F11R / JAM-A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human F11 Receptor / F11R / JAM-A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human F11 Receptor / F11R / JAM-A Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033607

      Synonyms:Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM;JAMA;JCAM;KAT

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM;JAMA;JCAM;KAT
      Species Human
      Expression_host Human Cells
      Sequence Ser28-Val238
      Accession Q9Y624
      Mol_Mass 23.89 kDa
      AP_Mol_Mass 28-31 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 100mM Glycine, pH 7.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.

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