Recombinant Human LAIR1 Protein (Fc Tag)

    • Recombinant Human LAIR1 Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human LAIR1 Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human LAIR1 Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030465

      Synonyms:CD305;LAIR-1

      Size:
      • 50 µg
      • 200 µg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CD305;LAIR-1
      Species Human
      Expression_host HEK293 Cells
      Sequence Met 1-Tyr165
      Accession Q6GTX8.1
      Mol_Mass 42.8 kDa
      Tag C-Fc

      Properties

      Purity >(86.1+10.4) % as determined by reducing SDS-PAGE..
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. 

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