Recombinant Human Langerin/CD207 Protein (His Tag)

    • Recombinant Human Langerin / CD207 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Langerin / CD207 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Langerin / CD207 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033707

      Synonyms:CD207 antigen; langerin; CD207; C-type lectin domain family 4 member K; C-type lectin domainfamily 4, member K

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $117

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      Overview

      Synonyms CD207 antigen; langerin; CD207; C-type lectin domain family 4 member K; C-type lectin domainfamily 4, member K
      Species Human
      Expression_host Human Cells
      Sequence Tyr64-Pro328(Val278Ala)
      Accession Q9UJ71
      Mol_Mass 31.5 kDa
      AP_Mol_Mass 30-40 kDa
      Tag N-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.

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      MSDS for ELISA ISO 9001

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