Synonyms	FLJ34254;FLJ35396;FLJ37216;FLJ54658;IGLON3;LAMP
Species	Human
Expression_host	HEK293 Cells
Sequence	Met 1-Asn 315
Accession	Q13449
Application	Functional ELISA
Mol_Mass	59.0 kDa
AP_Mol_Mass	80-85 kDa
Tag	C-hFc
Bio_Activity	Immobilized recombinant human OPCML-His at 10 μg/mL can bind recombinant human LSAMP-Fc with a linear range of 31. 25-250 ng/ml.

Properties

Purity	> 97 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions; also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule; serving as a guidance cue for specific patterns of connectivity; which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety; indicating a possible role of LsAMP in the regulation of anxiety.

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