Synonyms	Tumor Necrosis Factor Receptor Superfamily Member 3;Lymphotoxin-Beta Receptor;Tumor Necrosis Factor C Receptor;Tumor Necrosis Factor Receptor 2-Related Protein;Tumor Necrosis Factor Receptor Type III;TNF-RIII;TNFR-III;LTBR;D12S370;TNFCR;TNFR3;TNFRSF3
Species	Human
Expression_host	HEK293 Cells
Sequence	Gln31-Met227
Accession	P36941
Mol_Mass	22.8 kDa
AP_Mol_Mass	29-40 kDa
Tag	C-His
Bio_Activity	Not validated for activity

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Tumor necrosis factor receptor superfamily member 3; also known as Lymphotoxin-beta receptor;Tumor necrosis factor C receptor;Tumor necrosis factor receptor 2-related protein;Tumor necrosis factor receptor type III;LTBR;TNFCR; TNFR3 and TNFRSF3; is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types; but not on T and B lymphocytes. LTBR and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of LTBR can trigger apoptosis. In addition; LTBR can lead to the release of the cytokine interleukin 8.

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